Maybe it's just me as my eyes isn't that good (but no need for glasses yet) but I find it the text/background contrast isn't enough as in I think the text colour is a bit light. Specially the vote/answer/view columns
Coincidentally, I work in website accessibility - though I'm a product developer not an accessibility expert. The color contrast here (between #777 and #fff) is 4.48:1
This would not meet recommendations when measured against the most common accessibility standard, but only just. WCAG AA suggests a minimum contrast ratio of 4.5:1 for small text. I used the WebAIM checker (http://webaim.org/resources/contrastchecker/).
If SE could just bump that grey to be a little bit darker it would definitely benefit some of our users.
It is a little light on contrast. We'll fix it shortly!